The human body is beyond resilient. Press question mark to learn the rest of the keyboard shortcuts. I'm so happy since I lost the weight, I feel wonderful and I gained an interest in fashion with my new body. Roughly when it starts and when it peaks? Problem is, I haven't pushed myself enough to do another extended fast. All evidence and research I've done has pointed to the fact that the body will save the most valuable organs till the last of starvation. Not only that, the body will preferentially select the damaged cells within organs once it is forced to cannibalise them... and replace the cells with healthy ones during re-feeding. https://www.researchgate.net/publication/324236338_Autophagy_regulates_testosterone_synthesis_by_facilitating_cholesterol_uptake_in_Leydig_cells. You are amazing. It's a moot point as I haven't made the commitment to do either approach at this point. But it doesn’t hurt to try. I think that will be a slender look for me. I've looked up what dermatologists do, but I haven't heard of much success from anyone anywhere just getting their excess skin gone from topicals or nutrients. If Autophagy starts after 16 hrs of fasting, shouldn’t we fast longer than 16 hrs? But one thing bothered me, my soft water like jelly belly. I had been fluctuating between 104 to 120 lbs as I try to combat the skinny fat look by slowly gaining muscle and losing fat. When under nutrient deprivation, AMPK starts to inhibit cellular growth by suppressing the mTORC1 pathway [vii] [viii] , which in turn forces the body to catabolize its weakest components. I gained a bit this summer, so I figured this would be an excellent time to fast. Will 5 day fast with black coffee help? Check out this article about autophagy and ketosis. Like two days per week for two years. And you should do it for those reasons which are life changing!) Most of all, because my stomach is so loose it creates rolls and flabs that show up when I'm naked. Autophagy occurs constitutively in the normal myocardium, and disruption of this pathway results in development of left ventricular dilation and severe contractile dysfunction in the absence of any stress. The 2016 Nobel Prize in Physiology Or Medicine went to a Japanese scientist by the name of Yoshinori Ohsumi for his discoveries of the mechanisms behind autophagy, a cellular maintenance process - stimulated by fasting - that is critical in disease resistance, longevity and general body and brain vitality. We know the feeling of hunger but when you're at the point when you're truly starving that feeling! Hi , I am new here and dont know anything about autophagy . Bless you for all your hard work ! Skin is not much more than protein! I took quite a few of them, I just don't know what a good angle is to keep track of this. I'm not going to stuff my face with candy, but I'm going to keep low carbs, or even maintain my keto if I'm able to. I do believe it's possible. Yes or No will the body cannibalize the heart and brain well starving to death? Autophagy is a natural process by which our cells disassemble and remove their dysfunctional components. The most fascinating part of the discovery of autophagy is that the process is given a boost if there is cellular stress. Autophagy is real, but you may have to work at it to see the results you're looking for. From my personal experience if you do extended fasting and when eating stay in ketosis around 1800 Carloies for man it's only a matter of time! If it will work or not, then I'll share the results. I'd like to start up again shortly after Halloween. Fasting is perhaps the simplest way to trigger autophagy. Fasting and keto flow really well together. I'm thinking it may take multiple fasts before a noticeable change, but I'm curious to see how it goes. Autophagy is real, but you may have to work at it to see the results you're looking for. Do you get autophagy fasting for 16 hours? Autophagy is a natural regeneration process that occurs at a cellular level in the body, reducing the likelihood of contracting some diseases as well as prolonging lifespan. Perfect meal really proteins water and other elements. Whatever form of water fasting you practice, from IF to extended fasting and everything in between, and whether you're fasting for health, weight loss, self-discipline, longevity, or any of the other myriad benefits of fasting, you've come to the right place—a community of like-minded individuals sharing our knowledge and experiences. Weather it will work or not, we'll see. By using our Services or clicking I agree, you agree to our use of cookies. Looks like you're using new Reddit on an old browser. Hey, what do you think about fasting / IF to boost autophagy so it cleans brains / neurones from aggreagation of mutant proteins in neurones which are main cause of Neurodegenerative disease's such as Huntington. You're body will eat it. Notably, cardamonin showed higher autophagy flux in DAP1 siRNA group. How Long Until Autophagy. This is the time the body starting to go after the viable organs. Everything I've read and experienced myself leads me to believe that until I fast long enough to truly be in autophagy, I might lose weight, but the tumors won't be affected. People engage in IF to reap the many benefits to health, fitness, and mental clarity. We have shown that DCs have the ability to store antigen for a prolonged time in endo‐lysosomal compartments and thereby sustain MHCI antigen cross‐presentation to CD8 + T cells. And I'm doing great! Autophagy is a big topic in fasting communities (just making a note here, this post is not intended to be too analytical). The simple surgery is $10,000 more than I'm willing to pay. Does anyone know the timeline for autophagy during a fast? He talks about the correlation between increasing autophagy and increasing fasting time at 6:38, which is where the link for the video begins. This is what the source video here suggests: https://youtu.be/Sm8BIV5SYsM?t=398. Somehow, I'm guessing a repeating fast would be more effective over time, but that would require a commitment that I'm struggling with at this point. I had some loose skin from years earlier weight loss (I was on medication that ballooned me to over 320 lbs, I lost 100 of it and gained some back after my Dad died, to 240, and had been maintaining at 230-260 for years) tightened up. My goal weight is 175. I definitely have some extra fat there! Is the 16/8 fasting enough to trigger autophagy? Thanks! Autophagy and Ketosis. As a result, cell function actually improves when we’re under stress. It’s an evolutionary self-preservation mechanism … Sorry guys! Our spermidine-rich supplement allows you to reap the many benefits of autophagy more consistently. What freedom that gave me! Here I am suggesting only have snake juice for 72 hours to get one's body into autophagy. It allows the orderly degradation and recycling of cellular components. Not to worry when fasting. You have opened my eyes to a better way. Autophagy might not work, but also it might! Can anyone tell me ? Basically nothing is helping it go down so far... SOOO I'm going to give long term fasting a try! Does Autophagy actually starts earlier? They Scottish guy who water fasted for 382 days and went from something like 460 to 180 pounds did have his skin "shrink" back which is indeed unusual and I would suspect it was a combination of the effects of autophagy and that he was pretty young as I recall so his skin would have had more elasticity. Read on to learn about autophagy, its definition and how it works, autophagy regulation, and what factors increase it. Autophagy has been reported to be involved in supporting antigen cross‐presentation by dendritic cells (DCs). I think I took to much potassium, ugh! It's an n-1 result, but the fasting was the only thing I changed and I'd had that loose skin for years. Now I'm 199.8 and my skin so far doesn't feel lose. 5+ days is required, I don't see any way around it. It's just something that has to slowly go away on it's own for people who don't have very elastic skin like me. What Is Autophagy. I've included pictures from Imgur of my loose skin. Taken together, our results implied that DAP1 negatively regulates autophagy induced by cardamonin, and it may be a potential target for ovarian cancer therapy. How much photographic evidence have you seen of starvation victims with loose skin? OMAD, intermittent fasting, keto, short term fasting (up to 4 days), etc. The amount that it can endure and keep functioning is astonishing. I am researching how it affects autophagy & I am more confused then before I started researching. Fast for at least a week if you can healthily do it. I rub it with coconut oil, sea buckthorn seed oil, etc. As an anesthesia provider who has provided anesthesia for countless skin removal surgeries over the years, I am amazed at your results. The Sweet Spot for Intermittent Fasting. Even in a healthy human body, cells are constantly becoming damaged as a normal part of metabolic processes. (Started on November 12). Xo. Also gross, on the mobile version you can see my stomach on the main page. I've discovered that I'm capable of a 5 day fast at the very least and I plan on completing one more day for this particular one. I've played with the idea of doing a cycle of 10 day fasts, once a month, versus doing an extended 40 day fast. (Update) After the 1 week fast, I took a two week break. Just that in 21 days you are likely to have your body focus on other things (which are amazing too! Is 16 hrs enough? Trust me when I tell you, you will know this feeling and you will not be continuing your fast! Autophagy is the method by which your body cleans out damaged cells and toxins, helping you regenerate newer, healthier cells. Autophagy is fairly easy to measure. Autophagy is inherent in living organisms, including human beings. Insulin inhibits Autophagy, so fasting or keeping carbs low will be advantageous for Autophagy. This is exactly why Accord Nutrition has assembled a collection of the most potent and well-researched caloric restriction mimetics. I’ve only heard of one person who claimed to improve loose skin with fasting. ... help Reddit App Reddit coins Reddit premium Reddit gifts. I've read that black coffee and tea won't break a fast, but do they delay the onset of autophagy when fasting? I am considered underweight lower than 104 lbs and I have an interest in HEALTH, not being a mini pixy, therefore this is for loose skin, NOT being anymore skinnier. Fasting seems to work with skin but like others have said, the longer the better. Autophagy is your body's internal spruce-up system, cleaning out damaged cells and regenerating newer, healthier ones. Autophagy or autophagocytosis in fancy science language translates from the Ancient Greek word autóphagos which means self-digestion or -devouring. Press J to jump to the feed. Yeah for these kind of results we want for loose skin the longer the better. This article is protected by copyright. Nature has forever endowed the cells with such an incredible and useful ability – to process everything that seems superfluous or harmful. It's all just protein and water. my height is 6'1. I have one tumor that reduced from 4 cm to 2.5 cm after one 10 day water only fast. 5. That’s where the optimal autophagy … I also don't care about weight loss, in my case I have a series of benign tumor that I'm trying to get rid of. Been sipping salt water with my normal water using a tiny dainty spoon. Autophagy (from the Greek for self-eating ) is the regulated process by which a cell degrades its dysfunctional or foreign components. Thank you! Press question mark to learn the rest of the keyboard shortcuts. Autophagy can typically be activated with lifestyle interventions, such as exercise and diet changes. I bet it will work, but autophagy doesn't kick in until the 3rd day of fasting, icydn. To date, it has been well documented that inhibition of autophagy results in premature aging across a variety of species (Rubinsztein et al., 2011). However, to get into the therapeutic zone of autophagy you probably have to practice extended fasting that lasts over 24 hours and up to 3-5 days. I feel like it might take proper long term fasting. I feel better during those times, but the tumors haven't changed at all. A, Results of Live/Dead cell survival assay in control explants and explants treated with 1 μM, 5 μM, or 10 μM rapamycin for 48 hours. :). I still have fat to lose. Let autophagy eat you skin. Everyone wants to start saying crazy shit but what’s the research say? I found what helped me, a little cheat is to do keto between fast. Autophagy is a process that happens when your body recycles and gets rid … For now, I'm continuing my 3 day fast for as long as I can to see how well I do. Autophagy means “self-eating,” but rest assured, this is a good thing. It’s basically the recycling of cellular waste and taking out the trash. I'm interested to see your results. I watched a video that say if you fast for 17 hours and then break your fast with fat, And then you keep your protein under 20 g and your carbs under 50 g you will still be on autophagy. 12,35 Many studies have shown that proper upregulation of autophagy could slow down aging and lengthen life span. Autophagy also prevents the toxic accumulation of damaged cellular components in the body, especially mitochondria, and induces cell death. Going for 14+ hours without food causes short-term, reversible nutrient deprivation, which puts mild stress on your body, and your cells respond by becoming more efficient — turning on autophagy pathways and clearing out waste[* I also have Vinegar, but the rest of the stuff to make snake juice is still being shipped over to me. Autophagy has many other benefits: Promising Against Cancer. I do not have pictures because it was upper thigh/groin area and I did not take unflattering pictures of my groin, but my wife noticed and when I looked in the mirror, the loose skin was gone and there's much less chafing when I wear skirts and dresses. A lot of people are doing intermittent fasting in hopes of activating autophagy, boosting stem cells, and reversing aging.However, whether or not it’s going to work depends on how long you’re going to fast. Thanks for clarifying! I used to be 248.8lbs. Yeah you have the right idea of realizing that you have to do extended fasting three-plus days at least for the results we want. I recently started the standard 4+8+4 hr fasting but I’m confused. So we are back to me knowing of one person who has specifically reduced already-loose skin from fasting. If cells lack nutrients, are deprived of energy, or are damaged in some way, a “stress response” mechanism is activated, which initiates autophagy. Ted Naiman, M.D., whose great site is Burn Fat Not Sugar, posted the following graph recently (used with … I'll have to break it tomorrow evening because I'm getting a cap over a tooth and I have no idea how being in a fasted state will do. #1: Fasting. Maybe you’ll be the second person, and you’ll have the before and after pics to prove it! A lot of people are seeing great results from both and it works for many health problems, fat loss, and general wellbeing. Too much caffeine results in increased cortisol levels and excess cortisol can accelerate aging and result in fine lines, wrinkles, brown spots, dehydration, and skin damage. Skin is very thin and it wouldn't be puffy like that. I'm not that great at structuring these paragraphs, so if it seems all over the place, forgive me! I have low testosterone & would like to get treated. Nobody looks at my somach anyways except for me. Autophagy is the body’s way of cleaning out damaged cells, in order to regenerate newer, healthier cells. About 6 years ago, I went from weighing 176 lbs down to 106 lbs. I don’t know the person so I have no idea if their results were real. ?? Hello, I'm a frequent browser of this subreddit as well as a few other health related ones, but I don't post often. Would like to reduce a tumor too. It literally turns into an udder when I'm on my hands and feet and let it hang. In an interview with more noted IF-specializing doctors — Dr. Rhonda Patrick and Dr. Guido Kroemer — Kroemer mentions a study concluding that liver autophagy happens in shorter fasts. Just that your body gets a chance to repair. Excited to see your results. I am beginning an experiment for fasting and to see if it will improve my loose skin. I'd just like to see the full result Good job, keep going. This doesn't mean you have to drop your weekly calories. I also don't care about weight loss, in my case I have a series of benign tumor that I'm trying to get rid of. It's like soup! I am 33 years old, 5'2.5 and after a 3 day fast, I weigh 112.6 lbs. The level of autophagy was elevated by DAP1 silencing in SKOV3 cells. Now I'm on my second long term fast now for at least one week. Autophagy is a cell cycle process that has emerged as a crucial mechanism for life span extension in many different species. Check out this article. Or should it be a strict water fast? The site may not work properly if you don't, If you do not update your browser, we suggest you visit, Press J to jump to the feed. MTOR inhibits autophagy because it makes your body grow, whereas AMPK supports autophagy due to the energy-deprived state and burning of internal energy stores. However, as we age, experience stress, and deal with more and more free radical damage, our cells become damaged at an increased rate.. Autophagy activation was assessed by immunohistochemistry. What helped is realizing the lie that is 'starvation mode' as most people think of it. Autophagy was really only recognized a few years ago and a lot about it is still unknown. Thanks to it, cells are released from unnecessary parts, and the body as a whole – from unnecessary cells. Keto or not, it's said that autophagy leads to one of the main benefits of fasting. I have one tumor that reduced from 4 cm to 2.5 cm after one 10 day water only fast. Over time, our cells accumulate a variety of dead organelles, damaged proteins and oxidized particles that clog the body’s inner workings. I know this comment was several months ago, but I wanted to say that after a series of six 5+ day fasts (I made it to 5 days 20+ hours but never 6 days), I had loose skin tighten up. Very. I disagree. In fact, I kinda want buff arms later on. I did sit ups, push ups, etc to tone it a bit. What is autophagy? One of the biggest diet trends this year – keto and fasting. Autophagy (or autophagocytosis) (from the Ancient Greek αὐτόφαγος autóphagos, meaning "self-devouring" and κύτος kýtos, meaning "hollow") is the natural, regulated mechanism of the cell that removes unnecessary or dysfunctional components. New comments cannot be posted and votes cannot be cast. I listened to JRE podcast along with several health podcasts, watched mens fitness channels about body building, watched health lectures from doctors on youtube, read pub med articles and listened to numerous audiobooks. Intermittent Fasting(IF) is way of eating that restricts *when* you eat, usually on a daily or weekly schedule. Cookies help us deliver our Services. Autophagy Part 2 - How to maximize results Written by Chris on Apr 6, 2018 Last week, I went over how fasting triggers the process of autophagy to clean up damaged and dangerous cells in order to prevent diseases like cancer and dementia, improve your overall health and well-being, and actually slow the process of aging and extend your lifespan. That was a few years ago, since then I've tried anything that was a "fast" but wasn't extended water only. Patrick brings up the fact that a PROTEIN (called IGF-1) that must be depleted for autophagy to ramp up, is gone in about 12 hours. Written and Medically Reviewed by Dr Babar Shahzad, BSc and MBBS on January 23, 2020.. Autophagy is a cell-renewal process that has recently become associated with intermittent fasting. Fasting can only help to keep your skin autophagy more active and in so doing promote elasticity and general health. Our Autophagy Stack is the world’s very first supplement designed to start autophagy and support your goals of improving loose skin and wrinkles.. Autophagy Stack includes 6 different caloric restriction mimetics that are proven to help induce autophagy … Do you get autophagy on keto? I am interested in this, gonna follow to see the results. If you answered yes then the question becomes why wouldn't it go after skin? I'm a perpetually anxious girl, so please don't comment on my body unless it's about the subject at hand. In this article, you’re going to learn about the autophagy process, how it might benefit you, and how to induce autophagy … (Update) On day 5, I broke my fast with a premier protein bar, I felt absolutely horrible and every threw up a few times. Long term fast will assist, but my feeling is this one will take commitment like everything else. My question is this 50 g for the whole day or just one meal? I know that doing 40 day fasts isn't something a person should do more than a couple times a year. I've taken tumeric, Pycnogenol,and more recently Niagel. I have seen studies that low testosterone impairs autophagy, but I have also read that exogenous testosterone could impede it. While autophagy is very difficult to measure outside of a lab environment, many experts agree that the autophagy process initiates in humans after … Coffee consumption may have effects on Autophagy, a process of cellular component recycling that also occurs during intermittent fasting. I don't know what it's like. Throughout the years, the loose skin has reduced.... a tiny bit. I have some loose skin myself, i'm hoping to lessen. Hoping someone on here has some insight or experience. I've just completed my 5th day of fasting and now I'm on my 6th.